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Asian Journal of Animal and Veterinary Advances
  Year: 2010 | Volume: 5 | Issue: 6 | Page No.: 402-409
DOI: 10.3923/ajava.2010.402.409
 
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A Novel 15 bp Deletion Mutation at KAP16.5 Locus in Cashmere Goat of China

Liu Wu Jun, Fang Yi, Shao Yong-gang, Fang Guang Xin, Tian Ke Chuan, Huang Xi Xia, Chen Hong and Zhang Fu Quan

Abstract:
In this study, a novel deletion mutation in the whole CDS region at cashmere goat KAP16.5 gene locus is reported, which result showed the deletion of KAP16.5 gene in 816 cashmere goat samples was firstly detected in China. At the same time, parts of these samples sequenced. However, there are not many studies of goat KAP16.5 gene and its polymorphisms in literary sources. The polymorphism was studied in three Xinjiang local goat breeds of China. The results showed that there was 15 bp-deletion mutation in this gene. The frequencies of the KAP16.5-Y allele in Xinjiang goat (n = 220), Nanjiang cashmere goat (n = 310) and BoGeDa cashmere goat breeds (n = 286) were 0.9591, 0.8694 and 0.8846, respectively. The χ2-test showed that the genotype distributions in these three cashmere goat breeds were not in agreement with Hardy-Weinberg equilibrium. According to the classification of PIC, Nanjiang cashmere goat was more polymorphic at this locus. Moreover, the 15 bp-deletion mutation was described at KAP16.5 locus for the first time and not have described at KAP16.5 locus. Then, the deletion polymorphisms within the KAP16.5 have been associated with economic production traits data in Nanjiang cashmere goat breed shown no significant (p>0.05).
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How to cite this article:

Liu Wu Jun, Fang Yi, Shao Yong-gang, Fang Guang Xin, Tian Ke Chuan, Huang Xi Xia, Chen Hong and Zhang Fu Quan, 2010. A Novel 15 bp Deletion Mutation at KAP16.5 Locus in Cashmere Goat of China. Asian Journal of Animal and Veterinary Advances, 5: 402-409.

DOI: 10.3923/ajava.2010.402.409

URL: https://scialert.net/abstract/?doi=ajava.2010.402.409

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