Abstract: Background and Objective: The use of medicinal plants for therapeutic potentials and treatment of microbial diseases is popular and has been archived since time immemorial. Plants contain phytochemicals, which when utilized by humans give therapeutic and antibacterial effects. Gomphrena celosioides has not been reported to be edible rather it is mostly used for medicinal and ornamental purposes. The present study was carried out to evaluate the medicinal potentials by analyzing phytochemical and antibacterial activities of ethanolic leaf and stem extracts of Gomphrena celosioides. Materials and Methods: phytochemical analysis was done using standard gravimetric and spectrophotometric techniques whereas the antibacterial assay of leaf and stem extracts was carried out at different concentrations against some selected human microbes (Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) using standard agar diffusion method. The results were analyzed using Analysis of Variance (ANOVA). Results: Qualitative and quantitative phytochemical results indicated varied compositions of the secondary metabolites in leaf and stem extracts of G. celosioides. Antibacterial results indicated that the ethanolic leaf and stem extracts of G. celosioides inhibited the growth of the microbes assayed but at varying levels and the inhibition was extracted concentration-dependent. The leaf showed significantly higher inhibitory effects against the tested pathogens when compared to stem extract. Conclusion: The data obtained from the research indicated that the plant possessed antibacterial potentials and its uses in ethnomedicine are thus justified.