Abstract: This study investigated the epidemiology of Hepatitis C Virus (HCV) infection, among the patients attending the dental clinic of the Federal School of Dental Technology and Therapy, Enugu, between July and October 2008. Blood samples randomly collected from 100 patients were screened for hepatitis C virus antibody using Hepatitis C virus test strip (ACON, USA). Out of the 100 samples screened, 1% was positive. Although, HCV prevalence was low among the patients, its presence connotes the possibility of cross infection in dental settings in our environment. Consequently, strict adherence to standard precautionary measures by health and dental workers in Nigeria is hereby suggested.