Abstract: In the setting of neoplastic conditions, many biochemical substances deviate from their normal values; these may include proteins of body fluid. To verify this claim a prospective study was carried out to investigate the values of plasma proteins in salivary fluids in patients with primary brain tumors. This study had been conducted between September 2008 and July 2009 on 160 individuals. The qualified subjects for the study included, 80 patients (40 from each sex) with primary brain tumor and eighty age and sex normal subjects were used as control for salivary and serum proteins measurements. Concentrations of proteins were found higher in saliva and blood of male and female patients as compared with normal individuals. These results might suggest possible preliminary detection of primary brain tumor by observing the increase of protein concentration in the saliva of the patient which is easily carried out in clinical laboratory.