Abstract: Homocysteine, a sulphur containing amino acid is an intermediate product in the metabolism of L-methionine. The increased serum level of homocysteine is termed as hyperhomocysteinemia, which is implicated in neurological disorders, hepatic injury and renal dysfunction. In addition, hyperhomocysteinemia is considered to be an independent risk factor for various cardiovascular disorders such as atherosclerosis, hypertension, coronary artery diseases, arrhythmias and heart failure. The present review focuses on a brief discussion about homocysteine and its pathogenic role in cardiovascular disorders.