Abstract: At the present time heroine dependency is treated by methadone. In order to determine the effectiveness of another medicine named buprenorphine, an interventional study has been carried out. In this interventional study of 70 patients, we compared buprenorphine (2 mg) and low dose (20 mg) methadone as treatment for heroine dependence. Buprenorphine and methadone were administered daily for 15 days. There were 35 patients in each group. Comparison between groups for withdrawal sign and symptoms showed no significant differences. As compared with low-dose methadone and buprenorphine, it was shown that buprenorphine is a suitable treatment fore heroine addiction in term of decreased withdrawal sign and symptoms.