Abstract: Background and Objective: Schistosomiasis is a disease of medical importance. It is responsible for morbidities such as blood and protein deficiency in those infected. A study was carried out to determine prevalence and distribution of the Schistosoma mansoni and to determine effects of water contact activities on the prevalence and distribution of the disease. Materials and Methods: To determine Schistosoma mansoni prevalence in humans, 400 urine samples were tested for S. mansoni antigen using point of care circulating cathode antigen (POC-CCA) test kit. Questionnaires were also used to obtain information on water contact activities of residents of both Gwanje and Mada hills community. Results: In both Gwanje and Mada hills, males had higher relative prevalence of 73 and 69%, respectively. Children aged 11-20 years had significantly higher (p<0.05) prevalence than other age groups in both Gwanje (24.79%) and Mada hills (17.76%). Males had higher prevalence of S. mansoni in Gwanje than in Mada hill and males had significantly higher prevalence (p<0.05) than females in both Gwanje (33.70%) and Mada hills (19.04%). Fetching water for domestic use was the most done water contact activity and defecating was the least done water contact activity in both communities. Males preformed more water contact activities than females in both communities. Conclusion: Schistosomiasis is prevalent in both Gwanje and Mada hills and water contact activities of residents of the areas affect the prevalence and distribution of the disease.