Abstract: Background and Objective: Rice (Oryza sativa L.) is considered as one of the oldest and most important foods for the increasing world population. Rice is attacked by many diseases such as Bipolaris spicifera, Curvularia lunata, Fusarium spp., Nigrospora oryzae, Exserohilum rostratum, Alternaria spp. and Thanatephorus cucumeris and caused 50% yield losses in worldwide. Current research was designed to combine between more than 1 isolate of Trichoderma spp. to detect their compatibility and increase their effectiveness to control rice pathogens and plant diseases in general. Materials and Methods: Ten Trichoderma isolates (T.1-T.10) were combined with each other in the petri dishes. Four Trichoderma isolates T.4, T.6, T.7 and T.9 were chosen among the 10 Trichoderma isolates. Compatible Trichoderma isolates, T.4+T.7, T.4+T.9, T.6+T.7 that showed 100% homologies among them were then combined in one isolate T.4679. Results: The antagonistic ability parameter between compatible Trichoderma isolates T.4+T.7, T.4+T.9, T.6+T.7, T.4679 and 23 pathogens species of Bipolaris spicifera, Curvularia lunata, Fusarium spp., Nigrospora oryzae, Exserohilum rostratum, Alternaria spp. and Thanatephorus cucumeris revealed excellent potential to suppress the radial growth of pathogens after four days. Conclusion: Current study showed that Trichoderma isolate T.4679 exhibited high efficiency on reducing radial growth in B. spicifera, C. lunata, Fusarium spp., N. oryzae, E. rostratum, Alternaria spp. and T. cucumeris.