Abstract: The treatment of some intoxication cases represents a challenge for the physicians, especially which are caused by some toxic agents that have not antidotes. Recently, major efforts are being done via using specific characteristic effects of some plants to treat these cases as a safe and effective alternative or adjuvant therapy. Physalis peruviana L. is considered as one of these plants. It possesses bioactive compounds such as phenolic compounds that can inhibit the lipid peroxidation activities inducing an antioxidant effect. This review aimed to assess the protective and therapeutic effect of Physalis peruviana L. in the treatment of some intoxicated cases. This review discovered that Physalis peruviana can modulate the toxic manifestations of cigarette smoke, cadmium, carbon tetrachloride and acetaminophen on the different body organs such as the lung, testes, liver and kidney. Moreover, the administration of this plant can also be beneficial in protection against carcinogenesis process in the lung and liver because of its antioxidant and anti-proliferative effects.