Abstract: Background and Objective: Indigenous chickens as a source of meat and egg have made significant contributions to household food security throughout the developing world. The present study was aimed at evaluating the antibody titre of Nigerian chicken genotypes vaccinated with Salmonella and Newcastle vaccines. Materials and Methods: A total of 96 chickens were used for the study (24 normal feather, 24 frizzle feather, 24 naked neck, 24 exotic). Initial blood samples of the chicken were obtained from the wing vein and evaluated for Salmonella and Newcastle antibody titre using widal and haemagglutination inhibition test, respectively before vaccination. The birds were divided into two broad groups of 48 chickens each and treated with Salmonella and Newcastle vaccines, respectively. Blood samples were collected and analyzed at 3 and 5 days post vaccination. Results: Antibody titre was measured in the genotypes 3 days post vaccination with Salmonella vaccine as; 2.27 (frizzle feather), 2.14 (normal feather), 2.12 (naked neck) and 1.93 (exotic). The 3 days post vaccination titre with Newcastle vaccine were; 0.62 (Normal feather), 0.56 (frizzle feather), 0.51 (naked neck) and 0.09 (exotic). Responses to vaccination were significant (p<0.05) for antibody titre of the chicken vaccinated with Salmonella and Newcastle vaccines. The chickens showed significant responses to Salmonella vaccination and also, highest antibody titre was recorded in the birds 3 days post vaccination. Conclusion: It was concluded that frizzle and normal feather chicken genotypes showed more resistance to salmonella and Newcastle vaccines.