Abstract: Background: The life-style-related diseases, like hypertension and obesity is a global tendency. To prevent these diseases, researchers’ attention is increasingly focusing on pharmacological properties of some natural plants such as Undaria pinnatifida (wakame), the most widely eaten brown seaweed. Phytochemical studies of this seaweed exhibited the existence of many biologically active compounds, such as proteins, polysaccharide, fucoxanthin, macro and trace elements, as well as physiologically important fatty acids. Objective: This study reviews the main reports of the pharmacological properities of Undaria pinnatifida (wakame). Conclusion: The pharmacological active compounds of Undaria pinnatifida can be useful for the nutritional requirement of humans and may be beneficial in human health.