Abstract: In order to assess responses of eight soybean cultivars to drought stress and manganese foliar application, a field experiment was conducted as split plot based on randomized complete block design with three replicates at research station of Islamic Azad University, Kermanshah province, Iran during 2012, growing season. At the end of growing season, economic and biological yield were determined. Also, oil and protein contents in soybean grain were measured. Statistical analysis showed that irrigation and manganese interaction had significant effects on economic and biological yield, while, this treatment had no significant effects on oil and protein in soybean grain. In addition, there are significant differences among cultivars in economic and biological yield. Based on results obtained, withholding irrigation at flowering stage reduced oil, protein, economic and biological yield, but this reduction was not statistically significant for the oil. The lowest oil, protein, economic and biological yield were recorded in I2Mn0C2, I1Mn0C4, I2Mn0C5 and I2Mn0C4 treatments. There was a significant and positive correlation between economic yield with oil percentage and biological yield.