Abstract: Nature always stands as a golden mark to exemplify the outstanding phenomenon of symbiosis. Several developing countries as well as developed countries are using natural herbal medicines. The widespread use of herbal remedies and healthcare preparations has been described in ancient texts such as the Vedas and the Bible. The aim of the present study was to evaluate the antioxidant, antiinflammatory and antiulcer potentials of Momordica charantia seeds. Phytochemical screening of the seed extract showed presence of such phytoconstituents which have remarkable potential for the prevention as well as cure of some diseases. Antioxidant property of the extract was studied by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The extract showed maximum percentage inhibition of 61.43% by 1,1-diphenyl-2-picrylhydrazyl method at a concentration of 100 μg mL-1 as compared with the ascorbic acid. Further, it was evaluated for antiinflammatory activity by using carrageenan induced rat paw oedema. The extract showed significant reduction in the paw volume (62.79% reduction) at a dose of 500 mg kg-1. In case of antiulcer activity maximum % inhibition of gastric ulcer was found to be 62.85% in ethanol induced ulcer model and 69.6% in non steroidal antiinflammatory drug induced ulcer model at a dose of 100 mg kg-1 as compared with the standard ranitidine. The result of present study showed that seeds of Momordica charantia have been proven to be good natural source of antioxidant, antiinflammatory and antiulcer potentials.