Abstract: As the prevalence of congenital uterine anomalies in infertile women is high, therefore, detection of them accurately plays an important role in the final therapeutic success. The purpose of this study was comparison of sonohysterography findings in both infertile and fertile patients. Thirty eight infertile and 38 fertile female were enrolled in present study. SIS (saline infusion sonohysterography) was performed in every patient. The results of each group were compared with other group. In all of the fertile women, SIS revealed no polyp, myomas, asherman syndrome, stenosis of cervix, abnormality of the uterine cavity and also the oviduct tubes were opened. In the infertile patients, SIS revealed pathology in the uterine cavity in 10 out of 38 women. However, oviduct tubes were opened in all of the patients. Among 10 patients who had lesions in their uterine cavity, three had abnormalities related to the uterine cavity, five had endometrial polyps and two had submucous myomas. In addition, we observed 2 patients presented more than one polyp lesion and 1 patient had both a submucous myomas and an endometrial polyp lesion. There were not significant correlation between ages of the patients and the lesions (i.e., uterine polyp, myomas and intrauterine malformation) which were seen in them. SIS (saline in fusion sonohysterography) can be a reliable and accurate method for investigation of the endometrium and the uterine cavity. It can be a good alternative technique for the evaluation of uterine intracavitary malformation where office hysteroscopy is not available. SIS allows differentiation of intrauterine cavitary abnormality, without the use of ionizing radiation or contrast agents.