Abstract: Background and Objective: Oxidative stress is linked to many illnesses like cancer, diabetes, inflammatory disorder and aging. Thus, the search for plant reaches in polyphenolic compounds is apt to ameliorate these diseases. The present study aims at screening various solvent fractions of the methanol extract of Lophira lanceolata to ascertain it's in vitro antioxidant potentials. The antioxidant metabolites like phenolics and flavonoids were also quantified in the various solvent fractions. Materials and Methods: The methanol extract of Lophira lanceolata was purified using column chromatographic technique to afford n-hexane (HF), ethyl acetate (EF) and methanol (MF) factions respectively. The in vitro antioxidant activity of the solvent fractions was also determined while the Total Phenolics Content (TPC) was quantified using the Folin-Ciocalteu method and the Total Flavonoids Content (TFC) quantified colorimetrically using the aluminum chloride method. The total yield of the fractions and preliminary phytochemical analysis of the solvent fractions were also determined. Results: The phytochemical screening of the fractions revealed the presence of antioxidant metabolites like phenolics and flavonoids. The Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) of the fractions showed that EF had the highest value while HF had the least value. The half-maximal effective concentration (EC50) of the various fractions was generally lower showing that the fractions have potential antioxidant properties. Conclusion: The data obtained showed the solvent fractions of Lophira lanceolata act as an antioxidant due to its free radical scavenging potentials.