Abstract: Background and Objective: The traditional use of plant in managing disease conditions by people has been found effective and diseases resistance. About 75-80% of the world population used herbal medicines for primary health care as against the conventional hypertensive drugs. This study was aimed to determine the phytochemical and antioxidant potential in some selected medicinal plants used to manage hypertension conditions. Materials and Methods: The seeds of Arachis hypogea, Piper guineense, Parkia biglobosa, rhizomes of Curcuma longa, Zingiber officinale, fruits of Tetracarpidium conophorum, Musa paradisiaca and the leaves of Tapinanthus begwensis plants were collected in various villages in Osun state. Then, sample processing and chemical group detection was carried out. Local people were interviewed with the aid of semi-structural questionnaires. The plants that were used traditionally for the management of hypertension were documented. Phytochemical screening and quantitative analysis of the plants were determined. Also, the antioxidant assay was carried out using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH). Results: Alkaloids, saponins, tannins, phenol and flavonoids were relatively found present. Also, the antioxidant assay carried out using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) shown the percentage inhibition potential of the plants. Curcuma longa showed highest percentage inhibition while Arachis hypogaea has the least. Conclusion: The findings of phytochemical constituent and antioxidant potential of the selected medicinal plants supported their use for managing hypertension conditions.