Abstract: Background and Objective: Snake venoms constitute different toxins which display different modes of action. Likewise, venoms from different snake species vary significantly in their toxin composition. Snake venom can cause morbidity and even mortality through tissue destruction. Hence, this research was aimed at evaluating the protective effect of Azadirachta indica leaf extracts on renal and haematological indices in albino rats. Materials and Methods: A. indica leaf was collected, authenticated and extracted using methanol followed by fractionation using hexane and ethylacetate. Albino rats of both sexes were used. They were grouped into 5, normal control, venom control, venom and hexane fraction (100 mg kg–1 b.wt.), venom and ethylacetate fraction (100 mg kg–1 b.wt.), then venom and conventional antivenom. Results: The hexane and the ethylacetate fractions significantly rendered protection on the renal and haematological indices probably via inactivation of the venom cytotoxins. Conclusion: This research has provided a scientific proof on the antivenom properties of A. indica leaf and the plant extracts can be used for detoxification of the snake venom toxicity.