Abstract: Background and Objective: Bauhinia monandra leaves are prepared as poultices and used in many Brazilian tribes and some Nigerian communities for their antidiabetic, antioxidant and anti-inflammatory effect. Therefore, these folkloric claimed benefits inspired this study. The aim of this study was to evaluate the antioxidant potential of methanolic extract of Bauhinia monandra leaves (MEBmL) in vitro. Materials and Methods: In the present study, a preliminary phytochemical screening of MEBmL was done. Determination of the antioxidant activities was conducted using the 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, the hydrogen peroxide scavenging assay and the ferrous ion chelating ability test. Results: Phytochemical screening revealed the presence of flavonoids, saponins, tannins, alkaloids and proteins as major constituents and reducing sugars, steroids, cardiac glycosides and amino acids as minor constituents. The EC50 for MEBmL and L-ascorbic acid (positive control) in DPPH assay was 126 and 8.7 μg mL–1, respectively, while that of hydrogen peroxide scavenging assay and ferrous ion chelating ability was 155.86, 14.81, 128 and 32.10 μg mL–1, respectively. From the findings, it was observed that the methanolic extract B. monandra possessed significant antioxidant potential. Conclusion: The antioxidant activity of methanolic extract of B. monadra could have been due to the various phenolic phytoconstituents present in the extract. Thus, the findings suggests that the methanolic extract of Bauhinia monadra leaves could be a potential source of bioactive compounds with antioxidant properties and can be further exploited in further researches as potential antioxidants of therapeutic benefit in free radical induced diseases.