Abstract: Background and Objective: Since the beginning of mankind, plants have been regard as allies used in study. Several traditional medication systems employ herbal medicines for nephroprotection. This study was aimed at investigating the nephroprotective potential of Anthurium schlechtendalii (A. schlechtendalii) Kunth root consumption as a traditional medicine for kidney disease in Mexico. Materials and Methods: Oral administration of adenine (0.75%) induced chronic kidney disease and solid and aqueous extract from plant root. These were tested at doses of 125 mg kg–1/day and 1.8 mg mL–1/day, respectively in the animal model used in 4 weeks experiment. Growth parameters, liquid consumption, 24 h urine volume, kidney weight, creatinine, creatinine clearance, blood urea nitrogen (BUN) and urine proteins were determined and also statistically recognized by variance analysis procedures (one-way ANOVA), with a post hoc Tukey multiple range test for comparison of means (p<0.05). Results: The study shows that in groups IRDG, PG1 and PG2, body weight loss, increased fluid intake and also urine output were all observed to show significant differences in comparison to the other experimental groups. The mean kidney weight in these three groups was significantly greater, 3.1 and 3.3 fold for the right and left kidney, respectively. Induced renal damage was revealed by significantly higher levels of serum creatinine: 6.6 fold (IRDG) and 5.6 fold (PG1 and PG2), BUN levels were 15.1, 11.7 and 14.5 times higher and 24 h proteins were 15.4, 17.2 and 15 fold higher for IRDG, PG1 and PG2, respectively. Creatinine clearance levels decreased significantly: 12.8 fold (IRDG and PG2) and 15 fold (PG1). Conclusion: Using adenine-induced renal damage as a model and specific dose and administration time of A. schlechtendalii Kunth polar extract, the potential for its nephroprotective action or remission capacity was not evident in the animals under study. There must be more studies to follow this first one in order to accrue enough scientific knowledge that can support or reject medico-ethnobotanical uses or claims of A. schlechtendalii Kunth, particularly those linked with the renal or urinary system.