Abstract: The two plant species were obtained from Mau Forest Complex in the Rift Valley, Kenya. Various parts of the two plants: Bersama abysinicca Verdc. Family, Melathiaceae and Faurea saligna Harr. Family, Proctaceae have been used in vogue by the Ogiek communities, who inhabit the area as their indigenous home, as source of traditional medicines for several ailments of human and livestock. Bersama abysinicca bark has been used in the management of blackwater east coast fever and rift valley fever in cattle. This study carried antimicrobial screening to uncover new antimicrobial agents from higher plants thus exposing their potentials. It is also aimed at demystifying the secrecy in which traditional African medicine has been shrouded for centuries. In the past, there has been no scientific verification to validate the efficacy of the traditional phytomedicine in the Ogiek community. Three methods were used to obtain various plant extracts. The first method was by obtaining crude plant extracts using methanol as a solvent. The second method was used by obtaining crude plant extracts through sequential extraction with ethyl acetate and petroleum ether as the third. Results showed that different plant species exhibited various bioactivities either on fungi, bacteria or on both categories of pathogens. The plant species extracts exhibited bactericidal and antifungal activities. Further researches should be carried out into the possibilities of formulation and commercialization of the plants as phytomedicine.