Abstract: This study evaluated antioxidant potential of methanol extract of three Egyptian plants, Bauhinia alba (MEBA), Solanum rantonnetii (MESR) and Derris rubosta (MEDR) and also investigated their main phytoconstituents. The extracts leaves of the of the three plants were subjected to antioxidant assays, namely total antioxidant activity, reducing power, metal chelating, hydrogen peroxide, radical scavenging activities were studied according to in vitro methods at the different concentrations (25-100 μg mL–1) and each extract was subjected to phytochemical analysis. The results proved that MEBA had strong inhibition (%) of peroxide levels 84.88±0.83 when compared with the standards, such as BHA, TRO and RUT which have 82.03±1.04, 80.56±0.60, 78.50±0.41, respectively. The MEBA demonstrated effective reducing power, hydrogen peroxide scavenging activity and metal chelating activities. On the other hand, no correlation was found between antioxidant activity and total phenol and flavonoid contents. Chromatographic separation of MEBA proved the identification of betulin, betulinic acid, ursolic acid, kaempferol, isorhamnetin, kaempferol 3-O-α-rhamnoside, isorhamnetin 7-O-α-rhamnoside and rutin. Hence, it was concluded that Bauhinia alba has antioxidant activity and can be further employed for medicinal applications.