Abstract: The present study describes the antioxidant activity of Canthium coromandelicum for its medicinal values. Antioxidant compounds play an important role as a health defending factor and are called as free radical scavengers. Antioxidant activity or free radical scavenging activity of Canthium coromandelicum was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, nitric oxide radical, superoxide anion radical, reducing power and total antioxidant activity of this plant extract. In all the testing, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals. These results clearly indicate that Canthium coromandelicum is effective against free radical mediated diseases.