Abstract: This study was carried out to evaluate the hypoglycemic effect of unripe pulp of Carica papaya on streptozotocin induced diabetic albino rats. Thirty male albino rats were used for this study. The animals were examined by a veterinary doctor and allowed to acclimatize for two weeks. The animals were divided into three groups of 10-animals each. Group 1 (test), group 2 (induced control) and group 3 (normal control). Group 1 was fed with unripe pulp of pawpaw while group 2 and 3 were fed with a commercial feed (grower marsh). Samples from five animals were collected from each group after three weeks, another five samples were collected from each groups after five weeks. Plasma glucose level was determined by glucose oxidase method. The mean and standard deviation of the values obtained from group 1 (test) at week 3 and 5 were 56.0±6.0 and 35.8±6.9. The mean and standard deviation of the values obtained for group two (induced control) at week 3 and 5 were 155.0±8.0 and 159.0±4.3 and the mean and standard deviation of the values obtained for group 3 (normal control) were 113.2±3.4 and 112.0±3.2. All the results were statistically significant (p<0.05) at week 3 and 5 when compared with controls. This study revealed the hypoglycaemic effects of the pulp of unripe Carica papaya. Therefore, there is urgent need to conduct double-blind, randomized placebo-controlled human trial to decipher whether the same hypoglycemic effects could be obtained in human subjects.