Abstract: The study reveals that Ladakh is rich in medicinal flora and endemic diversity. The traditional knowledge on native plant species is highlights Amchi system of medicine and their traditional health-care system. The excessive extraction of medicinal plant resources for use in the pharmaceutical industry has resulted in ruthless destruction of natural populations of medicinal plants. Present study attempts to assess the current status of knowledge of medicinal plant resources and conservation status in Ladakh. An approach for prioritizing strategies for action is proposed which is a three step process, viz., technology development, technology dissemination, technology assessment and refinement. It also focuses on approach for prioritizing strategies for action is proposed.