Abstract: Extract of Globimetula braunii in different solvent systems were evaluated for possible lipid and blood pressure lowering activities using in vivo and in vitro experimental methods. Dried Globimentula brauni leaves were pulverized into powder and successively extracted with methanol, hexane, chloroform, ethyl acetate, n-butanol and water using hot extraction methods. Normal male adult albino rats were administered a dosage of 200 mg kg-1 b.wt. of the extracts for a period of 14 days and the level of total cholesterol, triacylglycerol and lipid peroxidation were monitored. The crude extract of Globimetula braunii was analyzed for some antihypertensive substances using High Performance Liquid Chromatography (HPLC). The results obtained, showed that different fractions of the extract caused significant (p<0.05) decrease in serum total cholesterol, triacylglycerol and malonyldialdehyde (MDA) levels. HPLC elution profile showed that the crude extract contained substances similar to some known antihypertensive drugs like propanalol, lisinopril, moduretic and nifidipine and the lisinopril-like compound seems to be the most abundant by having the highest concentration. Thus, the data from this study suggests that Globimetula braunii extract contains some biologically active substances that may lower blood pressure and serum lipids.