Abstract: A survey of useful medicinal plants of Okomu Forest Reserve was undertaken and a total of 60 species of plants comprising of 50 leafy plants and 10 mushrooms were identified and recognized to be useful in native health care services by inhabitants of various communities in the South-South of Nigeria. Different southern Nigerian communities show not only individual characteristic dialect, culture and therapeutic practices involving the application of ethnomedicinal plants but also share common indigenous folk knowledge of what plant is used for the treatment of which ailment. Studies also show that 75% of men in most rural communities visited have inherited ethnobotanical knowledge from their fathers.