Abstract: The effects of the ethanolic fruit extract of Parinari polyandra on lipid profile and electrolyte levels in pregnant rabbits were investigated. Graded concentrations of 0, 10, 50 and 250 mg kg-1 body weight of the extracts were administered by gastric intubations for a period of 14 days from the 12th -25th day of gestation after which they were fasted for 18 h. The following lipid profiles were examined in the serum. Triglyceride, Total Cholesterol, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) cholesterol. Serum electrolytes also examined were: Sodium (Na+), Potassium (K+), Calcium(Ca2+), Chloride (Cl¯), Bicarbonate(HCO3¯) and Phosphorus (P). After these durations of treatment, there was significant elevation in triglycerides (p<0.01). The LDL/HDL Cholesterol ratio was greater than 0.3 in all the treated groups. Also, there were significant elevations in Na+ (p<0.05), Cl-(p<0.05), P (p<0.05) and Ca2+ (p<0.05). The result therefore suggests that the ethanolic fruit extract of Parinari polyandra may predispose to hyperlipidemia and electrolytes imbalance leading to hypercalcaemia and high risk of raised blood pressure in pregnant rabbits.