Abstract: Chronic exposure to heavy metals through air, water, food and other media and product has serious negative health impact. Concentrations of heavy metals (Cd, Pb and Zn) in soil, water, Manihot esculenta tuber and Oreochromis niloticus around phosphates exploitation area in Togo were determined during dry and wet seasons using digestion and Atomic Absorption Spectrophotometer methods. In soil, Cd and Zn contents significantly decreased during dry season compared to wet season (p<0.001). During wet season, Akoumapé 2 and Akoumapé 3, Asso Apégan, had Cd concentrations in water lower than 0.003 mg L-1, however in dry season these concentrations were higher than the recommended maximum concentration. During wet season, all the sites had Pb concentrations (0.204 to 0.313 mg L-1) higher than values recommended by WHO. In cassava tubers, all Pb concentrations were below critical value of 2 mg kg-1; the highest concentrations of Cd (0.673 mg kg-1) and Pb (1.868 mg kg-1) were observed at Asso Apégan. Zn concentrations were below 60 mg kg-1 except at Agbozo Kpedzi where Zn level reached 104.660 mg kg-1. The values of Cd and Pb in Oreochromis niloticus at different sites were less than respectively 1 and 2 mg kg-1 except at Asso Apégan where Cd concentration during wet season reached 3.014 mg kg-1. The same site showed a maximum concentration of Zn (113.370 mg kg-1) during wet season higher than 100 mg kg-1. This study reveals that some sites of the exploitation zone of phosphate are polluted by the mining activities and constitute a risk to the population around through the food chain.