Abstract: The estuarine part of the Ebrie lagoon, close to the city of Abidjan, is contaminated by several persistent pollutants such as heavy metals, due to discharges from industrial and port wastes, agricultural and urban sewage. Water samples were collected from eighteen stations located in six bays for the analysis of nutrients (NO2¯, NH4+ and PO43¯) and heavy metals (Pb, Cd, Ni, Mn and Zn). Some important limnological parameters were also measured in situ. The samples were analyzed using colorimetric methods and with an Atomic Absorption Spectrophotometer (AAS) for nutrients and heavy metals, respectively. Levels of temperature, pH, salinity and conductivity were ranged save for aquatic life. Mean values of dissolved oxygen and transparency ranged from 1.62±1.62 to 7.26±2.24 mg L-1 and from 0.55±0.43 to 2.36±0.56 m, respectively. According to our data, hypoxia was observed in urban bays, around Abidjan. The analysis of water samples showed NO2¯, NH4+ and PO43¯ levels of mean values 0.152±0.234, 0.857±1.095 and 0.289±0.378 mg L-1 and 0.096±0.128, 0.592±0.758 and 0.295±0.393 mg L-1 in surface and bottom zones respectively. Highest levels for NH4+ and NO2¯ were found in surface waters, while PO43¯ recorded the highest levels in the bottom. For nutrients, significant difference (p<0.05) was observed between locations and seasons. The elemental toxicants Pb, Cd, Ni, Mn and Zn were identified in water of mean values 531.12±128.04, 19.19±12.35, 149.52±59.35, 92.80±22.79 and 19336.25±9960.60 μg L-1, respectively. According to the WHO recommended limits, waters collected at Bingerville, farther from Abidjan, were found to be suitable. Therefore, around Abidjan, apart from Mn, waters analyzed were found contaminated by Pb, Cd, Ni and Zn, with significant difference (p<0.05) between locations for Pb, Cd, Ni and Zn. Apart from Ni (p<0.001), there was no significant difference (p>0.05) between seasons, due to continuous inputs of these pollutants in the lagoon through anthropogenic activities during both seasons.