Abstract: Arsenic has been widely studied for its effects as a human carcinogenic agent but few studies have dealt with neurobehavioral effects. Gestation exposure is a time of high sensitivity to chemical, associated with an important risk factor for development of newborns of neurobehavioral dysfunctions. In the present study, we investigated in utero exposure studies to characterize developmental and behavioural alterations induced by arsenic exposure. Pregnant female Albino rats were exposed to inorganic arsenic (0, 4.5, 6.0 and 7.5 mg kg-1 day-1 by gavages) from gestation day 8 to till parturition and the offspring were observed over the first 3 postnatal weeks, until they were weaned on PND21. The offspring were examined for physical development, reflex development, strength and motor coordination through battery of test in order to evaluate their developmental neurotoxicity. The result of the study has not confirmed the high behaviours-teretrogenic potential of arsenic at given dose levels. Prenatal administration of arsenic failed to have physical development, neuromotor and reflex development, decreased exploration in the open field and delayed onset of negative geotaxis and startle reflex in arsenic-exposed animals in comparison to the control group. Present study demonstrated that, arsenic intoxication caused no significant alterations in the development of pups. Fetal effects such as mortality rate were observed but no maternal mortality was observed during the study with given doses. No statistically significant increases were observed for in utero deaths, resorptions and skeletal malformations during gestation day 8 to up to parturition with gavages. Prenatal administration of arsenic failed to induce neurobehavioral end points in rat suggest to pay increased attention to low level of arsenic concerning its exogenous use during pregnancy and further studies of dose-effect relationship are needed to assess the possible risk associated with arsenic exposure during gestation period.