Abstract: This study was aimed at investigating the effect of water and salt samples from Okposi and Uburu salt lakes on some serum trace elements and the cardiovascular system. Serum levels of copper (Cu), cadmium (Cd), cobalt (Co) manganese (Mn), cardiac troponin I (cTnI) and lipid profile were measured in albino rats after treating them with different doses of salt and water from the lakes for seven consecutive days. Average body weight, physical activities and food and intake decreased in all the treated groups compared with the control. The levels of Cu, Cd, Co and Mn in test groups were significantly higher (p<0.05) than in the control. There was a significant increase (p<0.05) in the concentrations of cardiac troponin I, cholesterol, triacylglycerol and low density lipoproteins, in the treated groups relative to the control while high density lipoproteins in the control were significantly higher (p<0.05) than the treated groups. The observations were also statistically more pronounced (p<0.05) in the groups given water samples than those administered salt samples. The differences in the levels of these parameters between groups given Okposi samples and those treated with Uburu samples were not significant (p>0.05). The effects of the samples were found to be dose- dependent. These results indicate that the samples may be toxic to the cardiovascular system and this toxicity may be reduced by the methods of processing the salt. The toxicity of the samples may be due to the chemical contents of the lakes.