Abstract: In order to investigate the effects of water stress on yield and yield components of 27 sesame genotypes, a factorial experiment based on randomized complete block design with three replications was conducted in 2006 in Moghan region, Iran. Factors were, 27 sesame genotypes (Karaj 1, Yekta, Oltan, Moghan 17, Naz takshakheh, Naz chandshakheh, Borazjan 2, Borazjan 5, Darab 14, Varamin 37, Varamin 237, Varamin 2822, Zoodrass IS, Hendi, Chini, Yellow white, 5089, Panama, Do-1, TF-3 , TKG-21, J-I, RT-54, Hendi 9, Hendi 12, Hendi 14 and Jiroft) and second factor was irrigation levels (complete irrigation and irrigation until flowering). Results showed that the highest yield belonged to Karaj1, Oltan, Naz takshakheh and Varamin 237 of 861.87, 863.47 and 859.73 kg ha-1. Naz takshakheh had the highest 1000-seed weight of 3.771 g. The highest seed No. per capsule and No. of capsule per plant was related to Chini and Naz chandshakheh genotypes of 107.250 and 99.13, respectively. So, Karaj 1, Oltan, Naz takshakheh and Varamin 237 genotypes in order to planting under drought stress conditions are recommended.