Abstract: The MPO is often released from stimulated polymorphonuclear leukocytes at sites of inflammation and is involved in the generation of reactive oxygen and nitrogen species and tissue damage. Thus, it can play a role of inflammatory skin disease such as psoriasis and subsequent development of cardiovascular comorbidities associated with psoriasis. To examine the association between serum myeloperoxidase and cardiovascular risk factor in psoriatic children in Damietta governorate. Fifty psoriasis children and fifty, age and sex matched controls were recruited from Pediatric and Dermatology Clinics at Al-Azhar University Hospital (New Damietta), Egypt. All were submitted to full history taking, clinical examination and laboratory investigation with measurement of myeloperoxidase serum levels. Present study showed that, there was significant increase of traditional risk factors for cardiac disease in study group when compared to control group. In addition, MPO was significantly increased in psoriasis patients (pointing to possible role in pathogenesis of psoriasis). However, there was no significant correlation between MPO and risk factors of psoriasis. On the other hand, there was significant positive correlation between MPO and duration of disease at the first followed by severity of the disease. The MPO played a role in pathogenesis of psoriasis. But, MPO do not play a role in development of CVD in children with psoriasis.