Abstract: This study concerns the modeling and analysis of Human Resource Management (HRM) and job satisfaction variables affecting Bangkok’s information technology career professional’s turnover intentions using both quantitative and qualitative research methods. From the trend of the growing information technology business in Thailand and as a result of human resource management, enterprise information technology business in Thailand has grown immensely. Quantitative research was conducted with 220 Bangkok career information technology professionals by the use of questionnaires and qualitative data was obtained from in-depth interviews of employees and management 10 senior level career professionals in the information technology business using simple random sampling (Purposive sampling) while using Partial Least Square (PLS-Graph) software to apply Structural Equations Modeling (SEM) analysis. Results showed the hypotheses had a significance level of p≤0.01, having a significant influence on human resource management and job satisfaction. Findings concluded that if an organization has good human resource management systems, the resultant factors will result in IT career professionals having greater work satisfaction resulting in higher retention rates amongst Bangkok IT professionals.