Abstract: The purpose of this study is to examine the influence of quality of Information System Success (ISS) on customer intention to continue use in B2B E-commerce. In addition, this study proposes a model to develop a contingency model from a system anxiety approach. One hundred and eleven online services professional users in Taiwan were recruited and Structural Equation Modeling was used to test the research hypotheses. The result indicates that how three dimensions of the using quality of information system success impacted trust. In addition, how three dimensions of trust have a positive direct effect on customer intention to continue use. In addition, system anxiety moderates the effect of quality of ISS on trust. Finally, this study discusses the theoretical and managerial implications of the findings.