Abstract: Background and Objective: Medicinal plants are important for primary healthcare needs of both rural and urban communities in Zimbabwe and among these are exotic plants. The aim of this study was to document exotic plants used as herbal medicines in Shurugwi District in South-central Zimbabwe. Materials and Methods: Semi-structured interviews, personal observations and guided field walks were conducted between December, 2014 and January, 2015 with 128 community members and traditional healers from seven villages to obtain ethnobotanical data on the use of exotic plants as herbal medicines. Data collected included names of exotic plants used, plant parts used, methods of herbal preparation and administration. Statistical Package for the Social Scientists (SPSS) was used to analyze collected data. Results: Total 26 exotic plants belonging to 15 families and 23 genera, mostly from Euphorbiaceae and Solanaceae (15.4% each), Asteraceae (11.5%), Apocynaceae and Myrtaceae (7.7% each) were used to traditionally manage 21 human and 4 animal diseases and ailments. The majority of the plant species used (69.2%) had one or two therapeutic uses. Plant species with at least three therapeutic uses were Bidens pilosa, Citrus lemon, Datura stramonium, Eucalyptus camaldulensis, Nicotiana tabacum, Psidium guajava and Schkuhria pinnata. Conclusion: This study revealed that exotic plant species play an important role in provision of primary health care to local communities in South-central Zimbabwe.