Abstract: The present study was to investigate the analgesic activity of the methanol extract of H. cordifolia bark by using in vivo animal model studies. The effect was studied using acetic acid-induced abdominal constriction test and formalin induced hind paw licking test in mice model. The results of the study showed that the extract exhibited significant analgesic effect. In acetic acid-induced writhing test, significant percentage of inhibition (78.48%) shows that at the dose of 400 mg kg–1 and at the same dose in formalin induced hand paw licking model shows significant activity in early phase (22.03% of inhibition) where in late phase (19.88% of inhibition) comparable to standard drug diclofenac sodium. These findings suggested that H. cordifolia bark has got the potential as a candidate for future analgesic agent.