Abstract: Background and Objective: Root-knot nematode is a serious pest of vegetables in India as well as in the world. The experiment was conducted in sick plots to evaluate the efficacy of organic amendment and bio-agents against the root-knot nematode, Meloidogyne incognita in cluster bean. Materials and Methods: Pseudomonas fluorescens, Purpureocillium lilacinum, Neem cake, P. fluorescens+Neem cake and P. lilacinum+Neem cake were used for management. Chemical check (Carbofuran 3G 10 g m–2) and the untreated check was also maintained. All the treatments were arranged according to RBD with three replications. Bio-pesticides were incorporated into the soil fifteen days before sowing. Results: Results revealed that highest yield and lowest nematode population were found in neem cake+P. fluorescens. Conclusion: Effects of organic amendments and bio-agents in combination significantly increase the yield of cluster bean and reduced nematode populations as compared to applied alone.