Abstract: Background and Objective: Human health is closely related to plants, especially with natural treatments such as; chemical fertilizers and composts as well as nano-particles and their use in a way that reduces the infection of plants with fungal diseases. The present study aimed to study the evaluation between role of nano-fertilizers and compost used on the soil fertility and their use in a way that reduces the infection of plants with fungal diseases. Materials and Methods: A field experiment was carried out during the Saumur seasons of 2018 and 2019 at Gelban village. The study was conducted to test the evaluation of foliar application of NPK nano-fertilizers and compost with or without mineral NPK fertilizers on some of the soil properties and soybean productivity. The design of the experiment was a complete randomized block with three replications. Results: The soil pH is characterized by slightly to moderately alkaline conditions, where the soil pH values are always around 7.95 to 8.08. The mean values of EC tented to 5.87 to 4.43. The highest of mean values is available in N, P, K, Fe, Mn and Zn contents in soil as affected by compost followed by NPK nano-fertilizers. The increase of plant characters and weight of seeds yield (t/fed) as affected with foliar application NPK nano-fertilizers combined with mineral NPK fertilizers at different rates. The application of compost or nano-NPK fertilizers was significant for Fe concentration in seeds, Mn and Zn concentrations were no significant. Conclusion: Application of NPK nano-fertilizers caused a reduction in incidence and severity diseases on plants in greenhouse and field experiments. In field experiments results indicated that the most effective treatment was NPK nano-fertilizers than control.