Abstract: Background and Objectives: Potato (Solanum tuberosum L.) established as the fourth main food crop worldwide. Based upon the accumulated data, the objective of this research was planned to study the possible effect of using antioxidants or formulated antioxidant (GAWDA®) on accelerating systemic acquired resistance in potato plants to overcome colonization and invasion of the common pathogenic fungi attacking the plants and tubers. This approach, if succeeded, it may be recommended to the potato growers as an innovative tactic to produce higher yield and quality tubers. Methodology: Potato tubers raised from wilted plants, grown in different locations presenting Dakahlia Governorate of Egypt were collected to isolate the common phytopathogenic fungi. In vitro studies were carried out to select the efficient concentration of the antioxidants tests for reducing the growth of the target fungi. In vivo studies were applied in the field plots at Mansoura University Campus. The growth parameters as well as the tubers weight and their quality characters were recorded. Data was statistically analyzed using CoStat 6.311 software of analysis of variance. The means were compared using least significant difference (LSD) at p<0.05 as outlined by Duncan. Results: Soaking tubers in 3.5 g L–1 of GAWDA® formulation for half an hour before planting followed by three times of spraying with the same concentration started on 30 days old plants followed by 15 days interval spray declined the diseases incidence and increased their production. Conclusion: Results address a strong correlation between the enhancing systemic acquired resistances of potato plants by green chemicals (Antioxidants) and controlling the soil-borne fungi attacking potato plants to produce quality tubers and higher yield.