Abstract: Rauwolfia serpentina (Indian snakeroot) is rich source of alkaloids, utilized for their medicinal properties. Diseases caused by foliar pathogens are major constraint in the economic production of the alkaloids from the dry roots of the plant. Among these diseases leaf spot caused by Cercospora rauwolfiae is of major importance, for its destructive nature resulting in huge economic losses. Management of the disease is achieved by use of chemical fungicides resulting in environment degradation and residual effect on the crop. Therefore in this study an attempt was made to evaluate the efficacy of commonly available essential oils and plant extracts for management of this destructive disease. Results of this study suggest that among the essential oils, mentha and peppermint oils at concentrations of 8 μL L–1 result in complete (100%) growth inhibition of the C. rauwolfiae while palmarosa oil was least effective in inhibiting in vitro growth (41.17%) of the fungus. In case of plant extracts garlic bulb extract was found to be most effective resulting in complete (100%) growth inhibition of the pathogen followed by neem, eucalyptus and turmeric respectively while leaf extract of the Ocimum gave minimum (17.25%) growth inhibition of the test fungus. Results of this study indicate that ecofriendly and effective management of Cercospora leaf spot of Rauwolfia serpentina can be achieved by using the metabolites (crude extract and essential oil) of plant origin.