Abstract: The aim of this study was to evaluate the possibility of exploiting mature compost of date palm by products in order to control Fusarium oxysporium f. sp. albedinis disease (Foa) commonly known as Bayoud. The obtained results showed that applying compost in mixture with peat and vermiculite S2 reduced significantly the losses of date palm seedlings of susceptible cultivar Bouffaggousse Gharasse due to the presence of Foa. However, the use of mixture substrate containing only peat and vermiculite S1 resulted in the death of 90% of the palm seedlings, as compared to non-infested S1. Also, the Foa population density and seedlings date palm mortality dropped in substrate mixtures S4 and S5 as the mature compost increased in soil substrate independently of date palm cultivar. The suppressive effect of compost seems reinforced by its richness of microorganisms having an antagonistic activity against Foa such as Aspergillus, Penicillium and Bacillus.