Abstract: Several fungicides were tested against some isolates belonging to four Fusarium species causing potato tuber dry rot in Tunisia. Incorporated into the culture media PDA, the tested fungicides significantly inhibited the mycelial growth, observed after incubation at 25°C for 4 days, of all Fusarium isolates including those of F. sambucinum resistant to benzimidazoles. A significant interaction (p ≤ 0.05) was observed between both fixed factors where inhibition percentage varied depending on tested pathogens and fungicides. Applied on potato tubers (tuber immersion for 10 min) prior inoculation, certain tested fungicides such as azoxystrobin and fludioxonil significantly reduced by more than 50%, comparatively to the untreated controls, the development of dry rot occasioned by F. graminearum and F. sambucinum observed after 21 days of incubation at 25-27°C. A significant interaction (p ≤ 0.05) was noted between the treatments and the Fusarium species traduced by a variable inhibition percentage depending on tested pathogen and fungicides.