Abstract: Epidemics of Fusarium Head Blight (FHB) occurred in Marmara Region in 1997 and 1998. FHB caused by Fusarium graminearum and Fusarium culmorum causing yield loss, Deoxynivalenol (DON) accumulation and poor quality of the crop. Fifteen Fusarium species were isolated from 9 counties in Marmara region. F. graminearum comprised 20.7% of the isolates, F. oxsporum 26.4%, F. culmorum 5.8% and the other species14.8 to <1 in this region. Thirty nine Turkish and east European cultivars and lines and twenty CIMMYT materials tested against FHB. Significant differences were found between FHB reactions of wheat cultivars and lines. Catbird (2279), Pamukova 97, Pehlivan, Marmara 86, Martar, BVD-7, SHA3/CBRD (38) and SABUF/3/BCN/CETA.AE.SQUAROSSA (895).(253) were found have low resistance to the disease. FHB incidence positively correlated with DON content. Thousand Kernel Weight (TKW) in all inoculated cultivars and lines was negatively correlated with Fusarium head blight percentage (FHB %).