Abstract: Background and Objective: The exploration of new and quality animal feed sources is very important for identifying supplements to the limited supply of grass. Palm oil processing industry byproducts, tithonia plants and corn waste have very good nutrient content for animal feed. The research objective was to study the potential of palm oil processing industry byproducts, tithonia (Tithonia diversifolia) and corn waste by in vitro digestion as feed ingredients for Etawa crossbred dairy goats (ECDGs). The long-term goal of this study was to obtain a concentrate ration formula by utilizing industrial byproducts of the palm oil industry, local forage of tithonia and corn waste, for ECDG with the ultimate goal of increasing the productivity of ECDGs to meet milk self-sufficiency by 2020. The theme of this study is in line with Andalas University’s Master Plan Research with a focus on Food Security. Materials and Methods: This study used a randomized complete design consisting of three treatment groups; (A) Concentrate Ration (CR)+Tithonia, (B) CR+Tithonia+corn waste and © CR+corn waste. Five replicates were used per treatment. The CR consisted of 30% palm kernel cake (PKC), 20% rice bran, 9% corn, 40% tofu waste and 1% mineral. The protein and crude fiber content of the CR was 13.78 and 13.32%, respectively. The data were analyzed using one-way analysis of variance (ANOVA) and differences between treatments were tested using the Duncan multiple range test (DMRT) with 5% confidence intervals. The variables measured were dry matter digestibility (DMD), organic matter digestibility (OMD), crude protein digestibility (CPD) and digestibility of fiber fractions (NDF, ADF and cellulose). Results: The results showed that DMD, OMD and digestibility of fiber fractions (NDF, ADF and cellulose) were greatest (p<0.05) in treatment B. However, treatments A, B and C did not affect the CPD and the results were significant. Conclusion: It was concluded that the combination of concentrate ration with tithonia and corn waste resulted in the highest in vitro digestibility.