Abstract: Objective: This study was conducted to compare different forms of selenium (Se) and its effects on metabolic, enzymatic and immunoglobulin serum profiles in growing rabbits. Materials and Methods: Seventy-five mixed sex growing APRI rabbits aged 5 weeks and weighing 662.2±9.07 g was assigned randomly into 5 experimental groups to evaluate the effect of dietary addition of Se in organic and inorganic forms with/or without vitamin E. The five experimental groups were as follows: The first group was fed ad libitum a commercial pelleted diet and kept untreated and served as a control, while the other groups (second, third, fourth and fifth) were fed the same diet but addition of 0.3 mg Se-yeast/kg diet as organic Se form (OSe), 0.3 mg OSe/kg diet plus 200 mg vitamin E/kg, 0.3 mg Se/kg diet as inorganic Se form (ISe) and 0.3 mg ISe/kg diet as Na2SeO3 plus 200 mg vitamin E/kg, respectively. The study was lasted for 8 weeks during the growing period, from weaning age (at 5 weeks) to marketing age (at 13 weeks). Results: The result revealed that addition different forms of Se with/or without vitamin. E caused significant increases in total protein (TP), albumin (Alb) and globulin (Glb) but these increases were still within normal range. No significant differences (p>0.05) were observed in the metabolic profile among treated groups. Insignificant differences were found among all experimental groups including the control one for both liver enzymes (ALT and AST). Also, results showed that there was non-significant difference between treated groups and the control group in serum creatinine (CR) and Urea-N. Different dietary Se source caused to increase values (p≤0.05) of serum IgG and IgM concentrations than that of the control group. Conclusion: It can be concluded that Se addition in either organic or inorganic form, in the diet of growing rabbit, exerted some benefits on the some metabolic and immunologic profiles which in turn may ameliorate weaned stress.