Abstract: Background and Objective: Current efforts to overcome hypertension have been predominantly based on medical treatment. Nutritional education and local food use are still limited in efforts to lower blood pressure. This study was conducted to analyze the effect of nutritional education intervention and the provision of chayote on changes in blood pressure of pre-diabetic high school teachers. Methodology: This research study is an experiment consisting of a sample of high school teachers (SMA) with pre-diabetes in Palu city. The number of subjects per group was 25 people and they were categorized as the following: Group I = Intervention of instant chayote, Group II = Nutrition education intervention and Group III = Nutrition education intervention and provision of chayote. Systolic and diastolic blood pressure was measured before and after intervention. Data analysis were performed using pairwise t-test and Wallis crucial test and significance was considered at p<0.05. Results: Change in the mean and standard deviation of systolic blood pressure after intervention with instant infusion of chayote was 15.24±10.54 mm Hg (p = 0.00), after nutrition education intervention was 3.12±12.34 mm Hg (p = 0.190) and intervention in combination of nutrition education and instant chayote were 14.48±12.00 (p = 0.00). The change in diastolic blood pressure after intervention with the administration of siam gourd was 11.24±8.29 mm Hg (p = 0.00), nutritional education intervention was 1.88±10.33 mm Hg (p = 0.253) and intervention in combination of nutritional education and chayote was 6.84±11.76 mm Hg (p = 0.005). Conclusion: Instant chayote interventions combined with nutritional education may significantly decrease systolic and diastolic blood pressures in pre-diabetic high school teachers.