Abstract: Background and Objective: Stroke is an acute brain disorder caused by an interruption in cerebral blood circulation, which suddenly (within seconds) or rapidly (within a few hours) arises and impairs circulation in focal areas of the brain. Stroke is a major health problem in the world and it is the third leading cause of death after heart disease and cancer and is the cause of major disabilities. This study aims to develop a risk factor model of stroke incidence in South Sulawesi. Materials and Methods: This research applied an analytic observational method with a control case that is an epidemiologic research design for the study of exposure level relationships with various disease conditions or other health problems. The study includes a stroke case sample and a non-stroke control patient samples. Analyses were performed using an odds ratio and logistic regression with a value of p = 0.05 considered significant. Results: The results showed there was a significant relationship between stroke and hypertension, with OR = 4.06, 95% CI: 3.25-5.07 and there was a relationship between diabetes mellitus and stroke incidence. There was a relationship between smoking and the incidence of stroke, with OR = 1.60, 95% CI: 1.23-2.07. There was a relationship between heart disease and the incidence of stroke, with OR = 1.81, 95% CI: 1.42-2.32. However, there was no relationship between stress and stroke incidence, with p = 0.619 (p>0.05) and OR = 1.9, 95% CI: 1.48-2.64. The value of OR = 1.10 with 95% CI: 0.75-1.63. Conclusion: Hypertension is the most significant risk factor for stroke incidence compared to other risk factors but all of these risk factors can be lowered by lifestyle modification.