Abstract: The effects of Acalypha wilkesiana leaves on serum ALT and AST activities and body weight of normal rabbits were investigated. Oral administration of the leaf, in the form of decoction prepared by mixing 5 g of air-dried powdered leaves in 10 ml distilled water, at a dose of 1 g/kg body weight for a period of 8 and 15 days, caused a significant increase (p<0.05) in the activities of serum ALT and a significant decrease (p<0.05) in AST activities in normal rabbits. The treatment also led to a significant reduction (p<0.05) on the body weight of the experimental animals. This effect of the plant is a reflection of the relative safety of the plant in the management of hypertension and its possible use as a weight reduction therapy.