Abstract: Present research work was conducted to study the clinical efficacy of coded herbal medicine Arthritin in comparison with Methotrexate for treatment of rheumatoid arthritis. One hundred patients with rheumatoid arthritis were randomly assigned into two groups, 50 in each group. Test group was treated with Arthritin and control group was treated with Methotrexate. The effect of both drugs for treatment of rheumatoid arthritis was observed before and after treatment. Comparison of data recorded by physician relating to these variables showed significant differences between test and control groups (p<0.05). The efficacy of the test treated medication (Arthritin) was superior as p = 0.03. Arthritin is more effective than the Methotrexate in the treatment of rheumatoid arthritis.